? NUS - National University of Singapor


Publications - Biomedical



2015

  1. Zhaohong Mi, Yuhai Zhang, Sudheer Kumar Vanga, Ce-Belle Chen, Hong Qi Tan, Frank Watt, Xiaogang Liu and Andrew A. Bettiol, Subwavelength imaging through ion-beam-induced upconversion, Nature Communications 6, Article number: 8832 (2015)

  2. Andrew A. Bettiol, Zhaohong Mi, Sudheer Kumar Vanga, Ce-belle Chen, Ye Tao, Frank Watt, Ion beam induced fluorescence imaging in biological systems, Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms B 348 (2015) 131-136

  3. Ye Tao, Zhaohong Mi, Sudheer Kumar Vanga, Ce-Belle Chen, Andrew A Bettiol, and Frank Watt. Variation in the uptake of Nanoparticles by Monolayer Cultured Cells using High Resolution Ion Beam Imaging . Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms B 348 (2015) 143-146

  4. Sudheer Kumar Vanga, Zhaohong Mi, Long Cheng Koh, Ye Tao, Andrew A. Bettiol, and Frank Watt. Development of a new light collection and detection system optimized for ion beam induced fluorescence microscopy. Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms B 348 (2015) 111-114

2013

  1. Xiao Chen, Ce-Belle Chen, Chammika N. B. Udalagama, Minqin Ren, Kah Ee Fong, Lin Yue Lanry Yung, Pastorin Giorgia, Andrew Bettiol and Frank Watt, High-Resolution 3D Imaging and Quantification of Gold Nanoparticles in a Whole Cell Using Scanning Transmission Ion Microscopy, Biophysical Journal 104 (7) (2013) 1419-1425

  2. F. Watt, X. Chen, C. Chen, C. N. B. Udalagama, J. A. van Kan, and A. A. Bettiol, Whole cell structural imaging at 20nm resolutions using MeV ions, Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms 306 (2013) 6-11

  3. Rattanaporn Norarat, Varpu Marjomki, Xiao Chen, Mi Zhaohong, Ren Minqin, Ce-Belle Chen, Andrew Bettiol, Harry J Whitlow, and Frank Watt, Ion-induced fluorescence imaging of endosomes, Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms 306 (2013) 113-116

  4. Watt, F., X. Chen, C. Ce-Belle, C. Udalagama, M. Ren, G. Pastorin and A. Bettiol, Fast Ion Beam Microscopy of Whole Cells. Cosmos 9 (2013) 1-10

2012

  1. Srinivasan Dinesh Kumar, Murugaiyan Vijaya, Ramar Perumal Samy, S. Thameem Dheen, Minqin Ren, Frank Watt, Y. James Kang, Boon-Huat Bay, Samuel Sam Wah Tay, Zinc supplementation prevents cardiomyocyte apoptosis and congenital heart defects in embryos of diabetic mice, Free Radical Biology and Medicine 53 (2012) 1595–1606

  2. M. Dolores Ynsa, Ren Minquin, Reshmi Rajendran, Teresa Pinheiro and Frank Watt. Consequences of a Fat Diet in the Distribution of Minerals within Pancreatic Tissues of Rats and Rabbits, Microsc. Microanal. 18, 1060–1066, 2012

  3. Reshmi Rajendran, Ren Minqin, John A. Ronald, Brian K. Rutt, Barry Halliwell, Frank Watt, Does iron inhibit calcification during atherosclerosis?, Free Radical Biology and Medicine 53 (2012) 1675-1679

  4. Binbin Zhang, Minqin Ren, Fwu-Shan Sheu, Frank Watt, Aryeh Routtenberg, Quantitative analysis of zinc in rat hippocampal mossy fibers by nuclear microscopy, Neuroscience Research 74, 17-24 (2012)

2011

  1. Chen Xiao, Chammika NB Udalagama, Chen Ce-Belle, Andrew Bettiol, Daniel Pickard, T. Venkatesan and Frank Watt, Whole cell imaging using fast and slow helium ions, Biophysical Journal 101 (2011) 1788-1793

  2. F. Watt, Xiao Chen, Armin Baysic De Vera, C. N. Udalagama, Ren Minqin, J. A. van Kan, A. A. Bettiol, The Singapore high resolution single cell imaging facility, Nuclear Instruments & Methods in Physics Research B 269 (2011) 2168-2174

2010

  1. C.T. Ng, J.J. Li, R. Perumalsamy, F. Watt, L.Y.L. Yung and B.H. Bay, Localizing cellular uptake of nanomaterials in vitro by transmission electron microscopy, In Microscopy: Science, Technology, Applications and Education, Editors: Antonio Méndez-Vilas and Jesús Díaz álvarez, Formatex Research Center, ISBN (13): 978-84-614-6189-9 December 2010

2009

  1. Reshmi Rajendran, Ren Minqin, Maria Dolores Ynsa, Gemma Casadesus, Mark A. Smith, George Perry, Barry Halliwell and Frank Watt, A novel approach to the identification and quantitative elemental analysis of amyloid deposits - Insights into the pathology of Alzheimer’s disease, Biochemical and Biophysical Research Communications 382 (2009) 91–95

  2. F. Watt, A.A. Bettiol, J.A. van Kan, M.D. Ynsa, Ren Minqin, R. Rajendran, Cui Huifang, Sheu Fwu-Shen, A.M. Jenner, Imaging of single cells and tissue using MeV ions, Nuclear Instruments & Methods in Physics Research B 267 (2009) 2113-2116

  3. Harry J. Whitlow, Minqin Ren, Jeroen A. van Kan, Thomas Osipowicz, Frank Watt, Characterisation of beam focus quality in biomedical nuclear microscopy: A Fourier optics approach, Nuclear Instruments & Methods in Physics Research B 267 (2009) 2149-2152

  4. Harry J. Whitlow, Minqin Ren, Jeroen A. van Kan, Thomas Osipowicz, Frank Watt, Angular and lateral spreading of ion beams in biomedical nuclear microscopy, Nuclear Instruments & Methods in Physics Research B 267 (2009) 2153-2156

  5. M.D. Ynsa, M.Q. Ren, R. Rajendran, J.N. Sidhapuriwala, J.A. van Kan, M. Bhatia, and F. Watt, Zinc Mapping and Density Imaging of Rabbit Pancreas Endocrine Tissue Sections Using Nuclear Microscopy, Microsc. Microanal. 15, 345–352, 2009

  6. Reshmi Rajendran, John A. Ronald, Tao Ye, Ren Minqin, John W. Chen, Ralph Weissleder, Brian K. Rutt, Barry Halliwell, and Frank Watt, Nuclear Microscopy: A Novel Technique for Quantitative Imaging of Gadolinium Distribution within Tissue Sections, Microsc. Microanal. 15, 338–344, 2009

2008

  1. Minqin Ren, Harry J. Whitlow, Ananda Sagari A. R., Jeroen A. van Kan, Thomas Osipowicz and Frank Watt, Figures of merit for focusing mega-electron-volt ion beams in biomedical imaging and proton beam writing, Journal of Applied Physics 103 (2008) 014902

2007

  1. Minqin Ren, Reshmi Rajendran, Pan Ning, Benny Tan Kwong Huat, Ong Choon Nam, Frank Watt, Andrew Jenner b, Barry Halliwell, Zinc supplementation decreases the development of atherosclerosis in rabbits, Free Radical Biology & Medicine 41 (2006) 222-225

  2. Reshmi Rajendran, Minqin Ren, Pan Ning, Benny Tan Kwong Huat, Barry Halliwell, Frank Watt, Promotion of atherogenesis by copper or iron-Which is more likely?, Biochemical and Biophysical Research Communications 353 (2007) 6-10

  3. Ren Minqin, J.A. van Kan, A.A. Bettiol, Lim Daina, Chan Yee Gek, Bay Boon Huat, H.J. Whitlow, T. Osipowicz and F. Watt, Nano-imaging of single cells using STIM, Nuclear Instruments & Methods in Physics Research B 260 (2007) 124-129

  4. Reshmi Rajendran, Minqin Ren, Pan Ning, Benny Tan Kwong Huat, Barry Halliwell and Frank Watt, Nuclear microscopy measurement of copper in atherosclerosis - Sensitivity and limitations to spatial resolution,Nuclear Instruments & Methods in Physics Research B 260 (2007) 136-140

  5. Ren Minqin, Huang En, Konstanze Beck, Reshmi Rajendran, Ben J. Wu, Barry Halliwell, Frank Watt and Roland Stocker, Nuclear microprobe investigation into the trace elemental contents of carotid artery walls of apolipoprotein E deficient mice, Nuclear Instruments & Methods in Physics Research B 260 (2007) 240-244

  6. Harry J. Whitlow, Minqin Ren, Jeroen A. van Kan, Frank Watt and Dan White, Exploratory nuclear microprobe data visualisation using 3- and 4-dimensional biological volume rendering tools,Nuclear Instruments & Methods in Physics Research B 260 (2007) 28-33

2006

  1. F. Watt, Reshmi Rajendran, Minqin Ren, B.K.H. Tan and Barry Halliwell, A nuclear microscopy study of trace elements Ca, Fe, Zn and Cu in atherosclerosis, Nuclear Instruments & Methods in Physics Research, Section B 249 (2006) 646-652

  2. Minqin Ren, Reshmi Rajendran, Pan Ning, Benny Tan Kwong Huat, Ong Choon Nam, Frank Watt, Andrew Jenner, Barry Halliwell, Zinc supplementation decreases the development of atherosclerosis in rabbits, Free Radical Biology & Medicine 41 (2006) 222-225

  3. PSP Thong, F. Watt, MQ Ren, PH Tan, KC Soo M Olivo, Hypericin-photo dynamic therapy (PDT) using an alternative treatment regime suitable for multi-fraction PDT, Journal of Photochemistry and Photobiology B 82 (2006) 1-8

  4. N.-G. Ilback, U. Lindh, R. Minqin, G. Friman, F. Watt, Iron and copper accumulation in the brain of coxsackievirus-infected mice exposed to cadmium, Environmental Research 102 (2006) 308-313

2005

  1. Reshmi Rajendran, Minqin Ren, Gemma Casadesus, Mark A. Smith, George Perry, En Huang, Wei Yi Ong, Barry Halliwell, Frank Watt, Nuclear microscopy of diffuse plaques in the brains of transgenic mice, Nuclear Instruments & Methods in Physics Research, Section B 231 (2005) 326-332

  2. N.G. Iback, C. Lindh, R. Minqin, G. Friman and F. Watt, Selenium and mercury are redistributed to the brain during viral infection in mice, Biological Trace Element Research 108 (1-3) (2005) 215-224

  3. M.Q. Ren, R. Rajendran, N. Pan, B.T.K. Huat, B. Halliwell and F. Watt, The protective role of iron chelation and zinc supplements in atherosclerosis induced in New Zealand white rabbits: A nuclear microscopy study, Nuclear Instruments & Methods in Physics Research, Section B 231 (2005) 251-256

  4. Ren Minqin, Reshmi Rajendran, Ning Pan, Benny Kwong-Huat Tan, Wei-Yi Ong, Frank Watt, Barry Halliwell, The iron chelator desferrioxamine inhibits atherosclerotic lesion development and decreases lesion iron concentrations in the cholesterol-fed rabbit, Free Radical Biology & Medicine 38 (2005) 1206-1211

  5. P.S.P. Thong, F. Watt, M.Q. Ren, K.C. Soo, M. Olivo, Investigating the role of calcium and biological trace elements in hypericin photodynamic therapy induced tumor cell death using nuclear microscopy, Nuclear Instruments and Methods in Physics Research B 231 (2005) 315-320

2004

  1. de-Ektessabi, A. ; Kawakami, T.; Watt, F., Distribution and chemical state analysis of iron in the Parkinsonian substantia nigra using synchrotron radiation micro beams, Nuclear Instruments & Methods in Physics Research, Section B 213 (2004) 590-594

2003

  1. Ren Minqin, Frank Watt, Benny Tan Kwong Huat , B Halliwell, Trace elemental distributions in induced atherosclerotic lesions using nuclear microscopy, Nuclear Instruments and Methods in Physics Research B 210 (2003) 336–342

  2. Kawakami, Takuo; ide-Ektessabi, Ari; Watt, Frank., Chemical state analysis of iron using synchrotron radiation micro beam - brain tissues of monkey with Parkinson's disease, Biomedical Research on Trace Elements (2003), 14(3), 210-214

  3. He, Yi; Thong, Patricia S.; Lee, Timothy; Leong, S. K.; Mao, Bo Y.; Dong, Fang; Watt, Frank., Dopaminergic cell death precedes iron elevation in MPTP-injected monkeys, Free Radical Biology & Medicine (2003), 35(5), 540-547

  4. Min-Qin Ren, Wei-Yi Ong, Xin-Sheng Wang and Frank Watt, A nuclear microscopic and histochemical study of iron concentrations and distribution in the midbrain of two age groups of monkeys unilaterally injected with MPTP, Experimental Neurology 184 (2003) 947– 954

  5. Ren Minqin, Frank Watt, Benny Tan Kwong Huat, and Barry Halliwell, Correlation of Iron and Zinc Levels with Lesion depth in newly formed Atherosclerotic lesionsFree Radical Biology & Medicine, Vol. 34, No. 6, pp. 746–752, 2003

2001

  1. Watt, F. ; Ren, M.Q.; Xie, J.P.; Tan, B.K.H.; Halliwell, B., Nuclear microscopy of atherosclerotic tissue: a review,Nuclear Instruments & Methods in Physics Research B 181 (2001) 431-436

  2. M. Q. Ren, J. P. Xie, X. S. Wang, W. Y. Ong, S. K. Leong and F. Watt, Iron concentrations and distributions in the parkinsonian substantia nigra of aged and young primate models,Nuclear Instruments & Methods in Physics Research B 181 (2001) 522-528

1999

  1. J Makjanic and F Watt, Nuclear Microscopy in Alzheimer’s disease,Nuclear Instruments and Methods B 150 (1999) 167-172

  2. MQ Ren, PSP Thong, U Kara and F Watt, Single cell elemental analysis using nuclear microscopy,Nuclear Instruments and Methods B 150 (1999) 179 – 184

  3. MQ Ren, Wei-Yi Ong, Jagoda Makjanic and Frank Watt, Changes in calcium and iron level in brains of rats during kainate induced epilepsy, Nuclear Instruments and Methods B 158 (1999) 418 – 423

  4. WY Ong, MQ Ren, J Makjanic, TM Lim and F Watt, A nuclear microscopic study of elemental changes in the rat hippocampus after kainate induced neural injury,Journal of Neurochemistry 72 (1999) 1574-1579

  5. D Ponraj, J Makjanic, P Gopalakrishnakone and F Watt, Nuclear Microscopy of normal and necrotic skeletal muscle fibres: An intracellular elemental microanalysis,Micron 30(6): (Dec 1999) 567-73

  6. SJ Makjanic, D Ponraj, BKH Tan and F Watt., Nuclear Microscopy investigations into the role of iron in atherosclerosis, Nuclear Instruments and Methods B 158 (1999) 356-360

  7. D Ponraj, J Makjanic, PSP Thong, BKH Tan, and F Watt. , The onset of athersclerotic lesion formation in hypercholesterolemic rabbits is delayed by iron depletion, FEBS letters 459 (1999) 218-222

  8. PSP Thong, F Watt, D Ponraj, S K Leong, Y He and TKY Lee., Iron and cell death in Parkinson’s disease: A nuclear microscopy study into iron rich granules in the parkinsonian substantia nigra of primate models, Nuclear Instruments and Methods B 158 (1999) 349-355

  9. MQ Ren, PSP Thong, J Makjanic, D Ponraj and F Watt., Nuclear Microscopy in the life sciences at the National University of Singapore, Biological Trace Element Research. 71-72 (1999) 65- 76

  10. F Watt, MQ Ren and PSP Thong. MicroPIXE investigations: Time sequencing studies in degenerative diseases, International Journal of PIXE, 9 nos 3,4 (1999) 189-197

1998

  1. Makjanic, Jagoda; McDonald, Brendan; Li-Hsian Chen, Christopher Philip; Watt, Frank. Absence of aluminum in neurofibrillary tangles in Alzheimer's disease, Neuroscience Letters (1998), 240(3), 123-126

  2. Ponraj, D.; Makjanic, J.; Tan, B. K. H.; Watt, F.. Does iron induce atherosclerotic lesion? An investigation using nuclear microscopy,Electron Microscopy 1998, Proceedings of the International Congress on Electron Microscopy, 14th, Cancun, Mex., Aug. 31-Sept. 4, 1998

1997

  1. A N Hogarth, PSP Thong, DJW Lane and F Watt, Nuclear microscope analysis of blood cells from the tropical ascidian Phallusai Phillipinensis,Nucl Instr and Meths B130 (1997) 402-406.

  2. F Watt, PSP Thong, AHM Tan and SM Tang, Nuclear Microscopy of single whole cultured cells: Beam damage studies, Nucl Instr and Meths B130 (1997) 188-192

  3. J Makjanic, B McDonald and F Watt, Nuclear microscopy study of neurofibrillary tangles in Alzheimers disease, Nucl Instr and Meths B130 (1997) 439-444

  4. PSP Thong, F Watt, R Paramananthan, B H Bay and K H Sit, Nuclear microscopy of single whole cultured cells: preparation and analysis of human Chang liver cells, Nucl Instr and Meths B130 (1997) 351-358.

  5. PSP Thong, Y He, T Lee and F Watt, Nuclear microscopic investigations into the elemental changes in the substantia nigra of unilaterally MPTP lesioned Parkinsonian monkeys, Nucl Instr and Meths B130 (1997) 460-466

  6. S M Tang, I Orlic, K N Yu, J L Sanchez, PSP Thong, F Watt and H W Khoo, Nuclear Microscopy study of fish scales,Nucl Instr and Meths B130 (1997) 396-402

1996

  1. F Watt., Nuclear Microscope Analysis in Alzheimers and Parkinsons disease: A review, Cellular and Molecular Biology (1996) 42 (1) 17-26

  2. J Makjanic, P Thong and F Watt. Nuclear microscopy in medical research: Investigations into degenerative diseases,Proceedings of the 7th International Symposium on Advanced Nuclear Energy Research, Takasaki, Japan (1996)

  3. K H Sit, R Paramanantham, B H Bay, H L Chan, K P Wong, P Thong and F Watt., Sequestration of mitotic (M-Phase) Chromosomes in Autophagosomes: Mitotic Programmed Cell Death in Human Chang Liver Cells Induced by an OH Burst from Vanadyl (4), The Anatomical Record 245:1-8 (1996)

  4. J Makjanic, P Thong and F Watt. Nuclear Microscopy in Medical Research: Investigation into Degenerative Diseases, Radiation and Industries 72 (1996) 35-39

  5. K H Sit, R Paramananthan, B H Bay, K P Wong, P Thong and F Watt., Induction of vanadium accumulation and nuclear sequestration causing cell suicide in human Chang liver cells, Experimentia 52 (1996) 778-785

  6. PSP Thong, J Makjanic and F Watt., A Review of Nuclear Microscopy and Applications in Medicine, Singapore Medical J. 37 (1996) 527-531

  7. PSP Thong, M Selley and F Watt., Elemental changes in athersclerotic lesions using nuclear microscopy, Cellular and Molecular Biology (1996) 42 (1), 103-110

  8. Y He, P Thong, T Lee, S K Leong, C Y Shi, P T H Wong, S Y Yuan and F Watt., Increased iron in the substantia nigra of 6-OHDA induced Parkinsonism rats: A nuclear microscopy study, Brain Research 735 (1996)149-153

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